Micky van de Ven Double Ends Everton's Run at New Home Ground
Micky van de Ven became the initial backline player to net two goals in a English top-flight match for Spurs since Jan Vertonghen in March 2013.
Key points
Micky Van de Ven heads home two times in first half
The home side's defender has goal disallowed after VAR review
Pape Matar Sarr nets final goal in 89th minute
The defeat is Everton's initial at their new ground
The Tottenham defender scored on two occasions as Tottenham extended their winning streak in away games in the top division and handed the Toffees their first defeat at their new home.
The Toffees were unbeaten in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having left Goodison Park behind after more than a century at the conclusion of last season.
But Tottenham's leader Van de Ven pounced twice from set-pieces in the first half to place their impressive record at jeopardy, and they were unable to mount a comeback before the midfielder - set up by former Toffees attacker the Brazilian - headed home a third to put the game to bed.
Jake O'Brien believed he had equalized the tally five minutes after the defender's first goal, glancing a bullet header past the Spurs keeper from an set-piece.
The Portuguese striker, meanwhile, missed a handful of chances, while the Italian goalkeeper made a succession of excellent saves to ensure Tottenham went five matches on the road unbeaten in the English top flight.
But the video assistant referee stepped in, instructing the match official to check the goal on the pitchside monitor and the official decided that the winger and Iliman Ndiaye were in an illegal position and had interfered with the Spurs keeper.
The win moves the manager's team into third place in the Premier League, a handful of points off local foes and table-toppers Arsenal.
Everton remain 14th and sit half a dozen points ahead of the drop zone.
Spurs breakdown: The defender excels in role at both ends of pitch
After a uninspiring midweek performance in the European competition against the French side, where they managed a mere attempts on target, the manager opted for Randal Kolo Muani in attack instead of former Toffees player the Brazilian.
The summer signing was unable to influence the game before being replaced for the substitute after 60 minutes on the pitch, but it turns out he wasn't needed in the end.
Defender the Dutchman converted into an attacking force to be reckoned with.
Tottenham's opening strike came from a well-worked set-piece play, with Rodrigo Bentancur directing the ball back across the face of goal for an free Van de Ven to head home.
And the captain - filling in as captain in Cristian Romero's absence - notched his second in added time as he rose above the England keeper to head home.
The Dutchman was just as impressive in defence, combining well with his defensive colleague as the duo dealt superbly with the 34 crosses thrown their way by the opposition.
Everton analysis: Toffees lacking finishing touch
Everton's recent stadium had been a fortress, but it seems the freshness may have faded somewhat and fans flocked to the gates after Sarr's final goal for Tottenham.
The break in Everton's unbeaten home run won't be a major concern for the manager, but their attacking woes will be.
The forward and the other striker - the Everton's pair of recognised strikers - had scored just one league goal combined before the weekend's outing.
And they were unable to add to that miserable tally on a damp and dreary evening on Merseyside.
Beto's performance was summed up when he opted to overhead kick a clear chance from near the goal, despite having room and opportunity to readjust for a more conventional attempt that would have challenged Vicario.
Barry, as well, failed to make an impact after replacing the starter in the 65th minute.
It was not for a shortage of chance. The majority of Everton's attacks came through Grealish and Ndiaye, who relentlessly whipped dangerous crosses into the Spurs penalty area.
Upcoming fixtures for these two sides?
Everton: The team head to Sunderland in the Premier League on Monday, 3 November at 20:00 GMT.
Tottenham: Spurs go to St James' Park on Wednesday, 29 October for their next round League Cup match against Newcastle.